Roads are closed in both directions on William Slim Drive in Giralang.
At approximately 4:10pm, ACT Fire & Rescue and ACT Ambulance Service responded to a two-vehicle crash on the bridge between Chuculba Crescent and Owen Dixon Drive.
Firefighters used hydraulic rescue tools to extricate one patient from the crash.
Paramedics are assessing two patients on scene for possible transport to hospital.
ACT Policing are on scene managing traffic.